Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.48 |
| ▸ | SRC | P12931 | 7/20 | 0.46 |
| ▸ | ZAP70 | P43403 | 6/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384008 | 0.81 | SYK (0.48) | SYKSRCZAP70CDK2PLK1 | |
| SCHEMBL5065692 | 0.81 | MAPK10 (0.43) | — | |
| SCHEMBL4388874 | 0.78 | SYK (0.70) | SYKSRCZAP70CDK2 | |
| SCHEMBL13924481 | 0.75 | SYK (0.77) | SYKSRCZAP70CDK2CYP1A1 | |
| SCHEMBL5227039 | 0.73 | SYK (0.54) | SYKSRCZAP70CDK2PLK1 | |
| SCHEMBL4397546 | 0.71 | CDK2 (0.50) | SYKSRCZAP70CDK2PLK1 | |
| SCHEMBL13924503 | 0.69 | SYK (0.78) | SYKSRCZAP70CDK2 | |
| SCHEMBL4386380 | 0.69 | SYK (0.66) | SYKSRCZAP70CDK2 | |
| SCHEMBL4391924 | 0.67 | SYK (0.43) | SYKSRCZAP70CDK2 | |
| SCHEMBL13924552 | 0.67 | SYK (0.66) | SYKSRCZAP70CDK2CYP1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751146-A2 | PYRIDINYL- OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | Cyclacel Limited (GB) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005075468-A2 | PYRIDINYL - OR PYRIMIDINYL THIAZOLES WITH PROTEIN KINASE INHIBITING ACTIVITY | CYCLACEL LIMITED (GB) | 2005-08-18 | — | — | WO | disclosed |