Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUAK1 | O60285 | 5/20 | 0.43 |
| ▸ | JAK2 | O60674 | 6/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | EIF2AK4 | Q9P2K8 | 3/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL521499 | 0.99 | NUAK1 (0.43) | NUAK1JAK2PIK3CDCSF1RCDK4 | |
| SCHEMBL520749 | 0.84 | JAK2 (0.48) | JAK2PTK2JAK3INSRALK | |
| SCHEMBL16530528 | 0.83 | JAK2 (0.40) | JAK2PTK2JAK3INSRALK | |
| SCHEMBL18410171 | 0.82 | LRRK2 (0.54) | NUAK1JAK2PIK3CDCSF1RCDK4 | |
| SCHEMBL522572 | 0.80 | JAK2 (0.60) | NUAK1JAK2PTK2INSRALK | |
| Hydrochloric Acid SCHEMBL2482184 | 0.80 | JAK2 (0.59) | NUAK1JAK2PTK2INSRALK | |
| SCHEMBL16530361 | 0.77 | NUAK1 (0.47) | NUAK1JAK2AURKBAURKCPTK2 | |
| SCHEMBL522067 | 0.76 | ALK (0.62) | NUAK1JAK2PTK2JAK3INSR | |
| SCHEMBL18410038 | 0.76 | ALK (0.63) | NUAK1JAK2PIK3CDCSF1RCDK4 | |
| SCHEMBL520776 | 0.75 | ALK (0.49) | JAK2PTK2INSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | claimed |
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | NUAK1 2136/4885JAK2 1/4885PIK3CD 197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.