Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 3/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3892996 | 0.83 | PDGFRA (0.53) | EGFRPDGFRAPDGFRBKDR | |
| SCHEMBL13739661 | 0.81 | SRC (0.60) | EGFRPDGFRAPDGFRBKDRSRC | |
| SCHEMBL3906011 | 0.79 | KDR (0.54) | PDGFRAKDRSRCTGFBR1 | |
| SCHEMBL3895896 | 0.79 | PDGFRA (0.49) | EGFRPDGFRAPDGFRBKDR | |
| SCHEMBL14967538 | 0.79 | PDGFRB (0.57) | EGFRPDGFRAPDGFRBKDRAXL | |
| SCHEMBL3927341 | 0.79 | FGFR2 (0.58) | EGFRPDGFRAPDGFRBKDR | |
| SCHEMBL25826950 | 0.79 | EGFR (0.60) | EGFRPDGFRAPDGFRB | |
| SCHEMBL5824622 | 0.78 | AXL (0.52) | EGFRPDGFRAKDRAXLSRC | |
| SCHEMBL7485861 | 0.78 | EGFR (0.66) | EGFRPDGFRAPDGFRBSRCTGFBR1 | |
| SCHEMBL14966472 | 0.77 | PDGFRB (0.58) | EGFRPDGFRAPDGFRBKDRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1827434-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | Amgen Inc. (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006060318-A2 | QUINOLINES AND QUINAZOLINE ANALOGS AND THEIR USE AS MEDICAMENTS FOR TREATING CANCER | AMGEN INC. (US) | 2006-06-08 | — | — | WO | disclosed |