Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.82 |
| ▸ | CCNE2 | O96020 | 15/20 | 0.82 |
| ▸ | CCNE1 | P24864 | 15/20 | 0.82 |
| ▸ | CDK2 | P24941 | 15/20 | 0.82 |
| ▸ | GSK3A | P49840 | 1/20 | 0.66 |
| ▸ | PRKDC | P78527 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3273594 | 0.99 | GSK3B (0.80) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL5223562 | 0.91 | GSK3B (0.82) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| Hydrochloric Acid SCHEMBL3273865 | 0.90 | GSK3B (0.80) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL5224389 | 0.90 | GSK3B (0.80) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| Hydrochloric Acid SCHEMBL3274498 | 0.89 | GSK3B (0.98) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| Hydrochloric Acid SCHEMBL3277832 | 0.89 | GSK3B (0.79) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL5219546 | 0.89 | GSK3B (1.00) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| Hydrochloric Acid SCHEMBL3274706 | 0.88 | GSK3B (0.98) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL5220043 | 0.88 | GSK3B (0.78) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| Hydrochloric Acid SCHEMBL3273957 | 0.88 | GSK3B (0.77) | GSK3BCCNE2CCNE1CDK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575942-B1 | COMPOUNDS HAVING SELECTIVE INHIBITING EFECT AT GSK3 | ASTRAZENECA AB (SE) | 2007-05-02 | — | — | EP | claimed |
| JP-2006512337-A | — | — | 2006-04-13 | — | — | JP | claimed |
| EP-1575942-A1 | NOVEL COMPOUNDS HAVING SELECTIVE INHIBITING EFECT AT GSK3 | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | claimed |
| WO-2004055009-A1 | NOVEL COMPOUNDS HAVING SELECTIVE INHIBITING EFECT AT GSK3 | ASTRAZENECA AB (SE) | 2004-07-01 | — | — | WO | claimed |