Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Indazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.66 |
| ▸ | IDO1 | P14902 | 1/20 | 0.66 |
| ▸ | CDK2 | P24941 | 1/20 | 0.66 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.43 |
| ▸ | WNT3A | P56704 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Indazole SCHEMBL4583780 | 0.89 | HSP90AA1 (0.76) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL27577839 | 0.86 | HSP90AA1 (0.70) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL6168428 | 0.82 | HSP90AA1 (0.76) | HSP90AA1IDO1CDK2ABCB1ALDH1A1 | |
| Indazole SCHEMBL29208977 | 0.82 | HSP90AA1 (0.76) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL6295 | 0.81 | — | — | |
| Indazole SCHEMBL29355507 | 0.81 | — | — | |
| Indazole SCHEMBL1221882 | 0.81 | HSP90AA1 (1.00) | HSP90AA1IDO1CDK2ABCB1ALDH1A1 | |
| Indazole SCHEMBL8415085 | 0.80 | HSP90AA1 (0.79) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL20985592 | 0.79 | HSP90AA1 (0.86) | HSP90AA1IDO1CDK2ABCB1CTNNB1 | |
| Indazole SCHEMBL27326012 | 0.79 | HSP90AA1 (0.86) | HSP90AA1IDO1CDK2ABCB1CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828182-A2 | THERAPEUTIC PYRAZOLO[3,4-B]PYRIDINES AND INDAZOLES | Warner-Lambert Company LLC (US) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006056873-A2 | THERAPEUTIC PYRAZOLO[3,4-B] PYRIDINES AND INDAZOLES | WARNER-LAMBERT COMPANY LLC (US) | 2006-06-01 | — | — | WO | disclosed |