Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3545964 | 0.91 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3543992 | 0.91 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL3543220 | 0.82 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3551371 | 0.81 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3545640 | 0.81 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL3549102 | 0.80 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3551852 | 0.80 | PDE4B (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3550834 | 0.80 | PDE4B (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3545960 | 0.80 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3551391 | 0.80 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802615-A1 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044955-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |