Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.81 |
| ▸ | BACE2 | Q9Y5Z0 | 19/20 | 0.81 |
| ▸ | CTSD | P07339 | 17/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5220300 | 1.00 | BACE1 (0.81) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL5222492 | 0.99 | BACE1 (0.82) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL5222896 | 0.99 | BACE1 (0.82) | BACE1BACE2CTSD | |
| SCHEMBL5220307 | 0.93 | BACE1 (0.70) | BACE1BACE2CTSD | |
| SCHEMBL5223351 | 0.93 | BACE1 (0.70) | BACE1BACE2CTSD | |
| SCHEMBL5220294 | 0.93 | BACE1 (0.70) | BACE1BACE2CTSD | |
| SCHEMBL5223338 | 0.93 | BACE1 (0.70) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL5222502 | 0.93 | BACE1 (0.71) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL5222497 | 0.93 | BACE1 (0.71) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL5222903 | 0.93 | BACE1 (0.71) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253198-B2 | Hydroxyethylamine derivatives for the treatment of Alzheimer's disease | GLAXO GROUP LIMITED (GB) | 2007-08-07 | — | — | US | claimed |
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | claimed |