Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.57 |
| ▸ | BACE1 | P56817 | 11/20 | 0.51 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.49 |
| ▸ | CTSD | P07339 | 4/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5928550 | 0.92 | KLK5 (0.60) | KLK5BACE1PSEN1PSEN2APH1B | |
| SCHEMBL5220817 | 0.91 | KLK5 (0.56) | KLK5BACE1PSEN1PSEN2APH1B | |
| SCHEMBL5221580 | 0.90 | KLK5 (0.60) | KLK5BACE1PSEN1PSEN2APH1B | |
| SCHEMBL5221574 | 0.90 | KLK5 (0.60) | KLK5BACE1PSEN1PSEN2APH1B | |
| SCHEMBL5222893 | 0.89 | KLK5 (0.59) | KLK5BACE1PSEN1PSEN2APH1B | |
| SCHEMBL5222884 | 0.89 | KLK5 (0.59) | KLK5BACE1PSEN1PSEN2APH1B | |
| SCHEMBL6205577 | 0.89 | KLK5 (0.59) | KLK5BACE1PSEN1PSEN2APH1B | |
| SCHEMBL5391805 | 0.87 | KLK5 (0.55) | KLK5BACE1PSEN1PSEN2APH1B | |
| SCHEMBL5391812 | 0.87 | KLK5 (0.55) | KLK5BACE1PSEN1PSEN2APH1B | |
| SCHEMBL5390340 | 0.87 | KLK5 (0.55) | KLK5BACE1CTSDBACE2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |