Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.73 |
| ▸ | BCR | P11274 | 9/20 | 0.69 |
| ▸ | LYN | P07948 | 4/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 10/20 | 0.68 |
| ▸ | KIT | P10721 | 6/20 | 0.68 |
| ▸ | KDR | P35968 | 4/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.64 |
| ▸ | EGFR | P00533 | 2/20 | 0.63 |
| ▸ | PRKCA | P17252 | 1/20 | 0.63 |
| ▸ | BRAF | P15056 | 2/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | DDX3X | O00571 | 1/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.60 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1653890 | 0.97 | ABL1 (0.69) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL3532229 | 0.94 | ABL1 (0.76) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL3526105 | 0.93 | ABL1 (0.75) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL3528980 | 0.92 | ABL1 (0.79) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL1654077 | 0.91 | ABL1 (0.72) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL1654184 | 0.90 | ABL1 (0.71) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL1654429 | 0.89 | ABL1 (0.79) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL3100773 | 0.87 | ABL1 (0.64) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL3536285 | 0.86 | ABL1 (0.76) | ABL1BCRLYNPDGFRAKIT | |
| SCHEMBL27803461 | 0.86 | ABL1 (0.62) | ABL1BCRLYNPDGFRAKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546127-B1 | NOVEL PYRIMIDINEAMIDE DERIVATIVES AND THE USE THEREOF | NOVARTIS AG (CH) | 2007-08-08 | — | — | EP | disclosed |