Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 16/20 | 0.55 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2564836 | 1.00 | HRH3 (0.55) | HRH3HRH1KDM4EMAPTTAAR1 | |
| SCHEMBL2564050 | 0.98 | HRH3 (0.55) | HRH3HRH1KDM4EMAPTTAAR1 | |
| SCHEMBL2565799 | 0.92 | HRH3 (0.58) | HRH3HRH1KDM4EMAPTTAAR1 | |
| SCHEMBL2560471 | 0.88 | HRH3 (0.72) | HRH3HRH1 | |
| SCHEMBL2563611 | 0.86 | HRH3 (0.70) | HRH3HRH1 | |
| SCHEMBL2563410 | 0.86 | HRH3 (0.70) | HRH3HRH1 | |
| SCHEMBL2566752 | 0.86 | HRH3 (0.49) | HRH3HRH1 | |
| SCHEMBL2560963 | 0.86 | HRH3 (0.70) | HRH3HRH1 | |
| Hydrochloric Acid SCHEMBL3552392 | 0.85 | HRH3 (0.69) | HRH3HRH1 | |
| SCHEMBL2563832 | 0.85 | HRH3 (0.50) | HRH3HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1790646-A1 | Isoquinoline und benzo[h]isoquinoline derivatives, their preparation and their therapeutical application as antagonists of histamine H3 receptor . | Sanofi-Aventis (FR) | 2007-05-30 | — | — | EP | claimed |
| EP-1790646-A1 | Isoquinoline und benzo[h]isoquinoline derivatives, their preparation and their therapeutical application as antagonists of histamine H3 receptor . | Sanofi-Aventis (FR) | 2007-05-30 | — | — | EP | disclosed |