Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 16/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668071 | 1.00 | CCNE2 (0.45) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL591167 | 1.00 | CCNE2 (0.45) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL591168 | 1.00 | CCNE2 (0.45) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL5223984 | 1.00 | CCNE2 (0.45) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL4669301 | 1.00 | CCNE2 (0.45) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL4668074 | 1.00 | CCNE2 (0.45) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL3161155 | 1.00 | CCNE2 (0.45) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL588976 | 0.94 | CCNE2 (0.41) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL588977 | 0.94 | CCNE2 (0.41) | CCNE2CCNA2CCNE1CDK2CCNA1 | |
| SCHEMBL10155859 | 0.91 | ADORA2A (0.45) | ADORA2AADORA3CDK1CDK5ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841768-A1 | PURINE DERIVATIVES ACTING AS A2A RECEPTOR AGONISTS | Novartis AG (CH) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006074925-A1 | PURINE DERIVATIVES ACTING AS A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2006-07-20 | — | — | WO | disclosed |