Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.72 |
| ▸ | CTSD | P07339 | 2/20 | 0.53 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4908727 | 0.90 | BACE1 (0.88) | BACE1CTSDBACE2 | |
| SCHEMBL4909315 | 0.84 | BACE1 (1.00) | BACE1CTSDBACE2 | |
| SCHEMBL13496328 | 0.83 | BACE1 (1.00) | BACE1CTSDBACE2 | |
| SCHEMBL4905079 | 0.83 | BACE1 (1.00) | BACE1CTSDBACE2 | |
| SCHEMBL4913285 | 0.83 | BACE1 (0.89) | BACE1CTSDBACE2 | |
| SCHEMBL3375254 | 0.82 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL3375250 | 0.82 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL4908074 | 0.81 | BACE1 (0.88) | BACE1CTSDBACE2 | |
| SCHEMBL4913252 | 0.79 | BACE1 (0.83) | BACE1CTSDBACE2 | |
| SCHEMBL4908180 | 0.79 | BACE1 (0.85) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799660-A2 | AMINO-CONTAINING COMPOUNDS WHICH INHIBIT MEMAPSIN 2 BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006034296-A2 | AMINO-CONTAINING COMPOUNDS WHICH INHIBIT MEMAPSIN 2 BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF | COMENTIS, INC. (US) | 2006-03-30 | — | — | WO | disclosed |