Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 15/20 | 0.73 |
| ▸ | TACR3 | P29371 | 2/20 | 0.65 |
| ▸ | TACR2 | P21452 | 1/20 | 0.65 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | FPR1 | P21462 | 1/20 | 0.63 |
| ▸ | GPR183 | P32249 | 1/20 | 0.63 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.63 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.63 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226612 | 0.93 | TACR1 (0.73) | TACR1TACR3TACR2NR3C1CYP3A4 | |
| SCHEMBL6621634 | 0.89 | TACR1 (0.79) | TACR1TACR3TACR2NR3C1CYP3A4 | |
| SCHEMBL5225840 | 0.85 | TACR1 (0.81) | TACR1TACR3TACR2NR3C1CYP3A4 | |
| SCHEMBL31355206 | 0.84 | TACR1 (1.00) | TACR1TACR3TACR2NR3C1CYP3A4 | |
| SCHEMBL15133362 | 0.84 | TACR1 (1.00) | TACR1TACR3TACR2NR3C1CYP3A4 | |
| SCHEMBL5223101 | 0.82 | TACR1 (0.80) | TACR1TACR3TACR2NR3C1CYP3A4 | |
| SCHEMBL5224196 | 0.81 | TACR1 (0.55) | TACR1TACR3TACR2NR3C1CYP3A4 | |
| SCHEMBL5226409 | 0.80 | TACR1 (0.75) | TACR1TACR3TACR2NR3C1CYP3A4 | |
| SCHEMBL29373930 | 0.79 | TACR1 (1.00) | TACR1TACR3TACR2NR3C1CYP3A4 | |
| SCHEMBL6228761 | 0.79 | TACR1 (1.00) | TACR1TACR3TACR2NR3C1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1462450-B1 | Substituted morpholine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME (GB) | 2007-06-13 | — | — | EP | claimed |
| EP-1462450-A1 | Substituted morpholine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2004-09-29 | — | — | EP | claimed |
| EP-1099702-A1 | Substituted morpholine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2001-05-16 | — | — | EP | claimed |
| EP-1462450-B1 | Substituted morpholine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME (GB) | 2007-06-13 | — | — | EP | disclosed |
| EP-1462450-A1 | Substituted morpholine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2004-09-29 | — | — | EP | disclosed |
| EP-1099702-A1 | Substituted morpholine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 2001-05-16 | — | — | EP | disclosed |
| US-5612337-A | ANALGESIC COMPOUNDS FOR PRODRUGS | MERCK SHARP & DOHME LIMITED (GB) | 1997-03-18 | — | — | US | disclosed |
| EP-0737192-A1 | SUBSTITUTED MORPHOLINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1996-10-16 | — | — | EP | disclosed |
| WO-1995018124-A1 | SUBSTITUTED MORPHOLINE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-07-06 | — | — | WO | disclosed |