Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.67 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.56 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5220522 | 0.94 | DPP4 (0.59) | DPP4DPP8DPP9 | |
| SCHEMBL14587278 | 0.92 | DPP4 (0.65) | DPP4DPP8DPP9 | |
| SCHEMBL14587279 | 0.92 | DPP4 (0.65) | DPP4DPP8DPP9 | |
| SCHEMBL5215962 | 0.90 | DPP4 (0.69) | DPP4DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL5148938 | 0.89 | DPP4 (0.68) | DPP4DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL5510013 | 0.89 | DPP4 (0.68) | DPP4DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL5510024 | 0.89 | DPP4 (0.68) | DPP4DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL5510011 | 0.89 | DPP4 (0.68) | DPP4DPP8DPP9 | |
| SCHEMBL14587272 | 0.81 | DPP4 (0.57) | DPP4DPP8DPP9 | |
| SCHEMBL14587273 | 0.81 | DPP4 (0.57) | DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1399433-B1 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-08-22 | — | — | EP | claimed |
| US-7183290-B2 | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-27 | — | — | US | disclosed |
| US-7183290-B2 | Fluoropyrrolidines as dipeptidyl peptidase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-27 | — | — | US | disclosed |
| EP-1399433-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2003002553-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-09 | — | — | WO | disclosed |