Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | ANPEP | P15144 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 3/20 | 0.37 |
| ▸ | MMP9 | P14780 | 3/20 | 0.37 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.37 |
| ▸ | MMP14 | P50281 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346522 | 1.00 | TP53 (0.40) | TP53MAPTTHRBGAALTA4H | |
| SCHEMBL3346528 | 1.00 | TP53 (0.40) | TP53MAPTTHRBGAALTA4H | |
| SCHEMBL5225277 | 1.00 | TP53 (0.40) | TP53MAPTTHRBGAALTA4H | |
| SCHEMBL3343365 | 0.91 | TP53 (0.41) | TP53MAPTTHRBGAAALDH1A1 | |
| SCHEMBL3342735 | 0.91 | PSEN1 (0.42) | TP53MAPTTHRBPSEN1PSEN2 | |
| SCHEMBL3343374 | 0.89 | HSD17B10 (0.44) | TP53MAPTTHRBLTA4HANPEP | |
| SCHEMBL3343297 | 0.89 | HSD17B10 (0.44) | TP53MAPTTHRBLTA4HANPEP | |
| SCHEMBL3343221 | 0.89 | GRM7 (0.35) | LTA4HANPEPMMP2MMP9MMP1 | |
| SCHEMBL3343216 | 0.89 | GRM7 (0.35) | LTA4HANPEPMMP2MMP9MMP1 | |
| SCHEMBL3342765 | 0.87 | GAA (0.42) | TP53MAPTTHRBGAALTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845089-A1 | Novel lactams and uses thereof | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |