Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346163 | 1.00 | HSD17B10 (0.55) | HSD17B10KDM4EPOLBTDP1USP2 | |
| Ammonia Solution, Strong SCHEMBL6208637 | 0.99 | HSD17B10 (0.54) | HSD17B10KDM4EPOLBTDP1USP2 | |
| SCHEMBL4125092 | 0.85 | HSD17B10 (0.51) | HSD17B10KDM4EPOLBTDP1USP2 | |
| SCHEMBL10352935 | 0.84 | HSD17B10 (0.61) | HSD17B10KDM4EPOLBTDP1USP2 | |
| SCHEMBL5229108 | 0.84 | HSD17B10 (0.40) | HSD17B10KDM4EPOLBTDP1USP2 | |
| SCHEMBL3545953 | 0.82 | HSD17B10 (0.55) | HSD17B10KDM4EPOLBTDP1USP2 | |
| SCHEMBL5224313 | 0.82 | HSD17B10 (0.55) | HSD17B10KDM4EPOLBTDP1USP2 | |
| SCHEMBL3342782 | 0.81 | HSD17B10 (0.47) | HSD17B10KDM4EPOLBTDP1USP2 | |
| SCHEMBL3345261 | 0.81 | POLB (0.47) | HSD17B10KDM4EPOLBTDP1USP2 | |
| SCHEMBL3340581 | 0.77 | PSEN1 (0.46) | HSD17B10KDM4EPOLBTDP1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1817306-A1 | TRIAZOLES AND THEIR USE AS BRADYKININ B1 RECEPTOR ANTAGONISTS | Amgen, Inc (US) | 2007-08-15 | — | — | EP | claimed |
| WO-2006044355-A1 | TRIAZOLES AND THEIR USE AS BRADYKININ B1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2006-04-27 | — | — | WO | claimed |