Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 6/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | RPA1 | P27694 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230295 | 0.84 | CCNA2 (0.53) | CDK2CCNA2CCNA1TRPV1L3MBTL1 | |
| SCHEMBL5228781 | 0.81 | CCNA2 (0.54) | CDK2CCNA2CCNA1TRPV1L3MBTL1 | |
| SCHEMBL12886440 | 0.79 | CDK2 (0.46) | CDK2CCNA2CCNA1TRPV1L3MBTL1 | |
| SCHEMBL5225870 | 0.79 | CDK2 (0.56) | CDK2CCNA2CCNA1TRPV1L3MBTL1 | |
| SCHEMBL5228034 | 0.79 | GAA (0.44) | CDK2CCNA2CCNA1TRPV1L3MBTL1 | |
| SCHEMBL5229147 | 0.78 | CCNA2 (0.56) | CDK2CCNA2CCNA1TRPV1L3MBTL1 | |
| SCHEMBL5229613 | 0.78 | CCNA2 (0.57) | CDK2CCNA2CCNA1TRPV1PDE4D | |
| SCHEMBL5231857 | 0.77 | CCNA2 (0.46) | CDK2CCNA2CCNA1TRPV1L3MBTL1 | |
| SCHEMBL5230183 | 0.76 | MAPT (0.46) | CDK2CCNA2CCNA1TRPV1L3MBTL1 | |
| SCHEMBL5228539 | 0.75 | CCNA2 (0.43) | CDK2CCNA2CCNA1TRPV1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478357-B1 | TRICYCLIC PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PFIZER ITALIA SRL (IT) | 2007-01-31 | — | — | EP | claimed |