Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | NPY1R | P25929 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344866 | 0.81 | ACE (0.51) | KDM1AMAOBKMT2AL3MBTL1 | |
| SCHEMBL4902997 | 0.81 | ACE (0.51) | KDM1AMAOBKMT2AL3MBTL1 | |
| SCHEMBL4905986 | 0.80 | TSHR (0.44) | KDM1AMAOBKMT2AL3MBTL1 | |
| SCHEMBL4905957 | 0.80 | TSHR (0.44) | KDM1AMAOBKMT2AL3MBTL1 | |
| SCHEMBL4906121 | 0.77 | ABCB1 (0.40) | KDM1AMAOBSCN9ANFKB1NFKB2 | |
| SCHEMBL4912762 | 0.74 | IDO1 (0.43) | KDM1AMAOBNFKB1NFKB2RELA | |
| SCHEMBL4900102 | 0.74 | IDO1 (0.43) | KDM1AMAOBNFKB1NFKB2RELA | |
| SCHEMBL1561640 | 0.72 | MME (0.43) | SCN9A | |
| SCHEMBL5400731 | 0.71 | MME (0.41) | NFKB1NFKB2RELAKMT2ANAAA | |
| SCHEMBL7349910 | 0.70 | ACE (0.63) | KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845089-A1 | Novel lactams and uses thereof | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |