Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5228478 | 0.92 | NPC1 (0.41) | TP53BRAFNPC1RAB9AMAPT | |
| SCHEMBL5230055 | 0.89 | BRAF (0.39) | MEN1KMT2ALMNAMAPK1ALDH1A1 | |
| SCHEMBL5226236 | 0.89 | BRAF (0.45) | BRAFNPC1RAB9AMAPTHDAC6 | |
| SCHEMBL4978728 | 0.88 | BRAF (0.37) | GRM5MEN1KMT2AUSP2CYP1A2 | |
| SCHEMBL5224254 | 0.82 | KDR (0.38) | GRM5CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL4980380 | 0.80 | BRAF (0.37) | AURKABRAFNPC1RAB9AMAPT | |
| SCHEMBL5225363 | 0.80 | RAF1 (0.39) | AURKABRAFNPC1RAB9AMAPT | |
| SCHEMBL4983383 | 0.80 | NPC1 (0.38) | BRAFNPC1RAB9AMAPTPOLB | |
| SCHEMBL4983374 | 0.79 | BRAF (0.44) | CYP3A4BRAFNPC1RAB9A | |
| SCHEMBL4980603 | 0.78 | BRAF (0.39) | MEN1KMT2ALMNAMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |