Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 18/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5131486 | 0.91 | TRPV1 (0.80) | TRPV1HDAC6 | |
| SCHEMBL5800285 | 0.89 | TRPV1 (0.80) | TRPV1HDAC6 | |
| SCHEMBL5800485 | 0.88 | TRPV1 (1.00) | TRPV1HDAC6 | |
| SCHEMBL5800442 | 0.88 | TRPV1 (0.78) | TRPV1HDAC6 | |
| SCHEMBL5799101 | 0.88 | TRPV1 (1.00) | TRPV1HDAC6MAPT | |
| SCHEMBL5126009 | 0.85 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL5803304 | 0.85 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL5803749 | 0.85 | TRPV1 (0.67) | TRPV1HDAC6 | |
| SCHEMBL5132530 | 0.84 | TRPV1 (0.73) | TRPV1HDAC6 | |
| SCHEMBL5126093 | 0.84 | TRPV1 (0.74) | TRPV1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799661-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | claimed |
| WO-2006038871-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | claimed |
| EP-1799661-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | AstraZeneca AB (SE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038871-A1 | NEW HYDROXYMETHYLBENZOTHIAZOLES AMIDES | ASTRAZENECA AB (SE) | 2006-04-13 | — | — | WO | disclosed |