Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4976870 | 0.90 | SLC2A1 (0.34) | SLC2A1CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL14274326 | 0.89 | CYP3A4 (0.32) | CYP3A4CYP2D6CYP2C9CYP2C19KDR | |
| SCHEMBL4978637 | 0.86 | KDR (0.35) | CYP3A4CYP2D6CYP2C9CYP2C19KDR | |
| SCHEMBL4976646 | 0.86 | KDR (0.37) | CYP3A4CYP2D6CYP2C9CYP2C19KDR | |
| SCHEMBL4978772 | 0.85 | KDR (0.37) | CYP3A4CYP2D6CYP2C9CYP2C19KDR | |
| SCHEMBL4980540 | 0.85 | MAPK14 (0.35) | CYP3A4CYP2D6CYP2C9CYP2C19KDR | |
| SCHEMBL14263381 | 0.84 | BRAF (0.36) | KDRRAF1 | |
| SCHEMBL4978572 | 0.84 | MAPK14 (0.37) | CYP3A4CYP2D6CYP2C9CYP2C19KDR | |
| SCHEMBL14274187 | 0.83 | KDR (0.34) | CYP3A4CYP2D6CYP2C9CYP2C19KDR | |
| SCHEMBL14263321 | 0.80 | BRD4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7338959-B2 | Diamino-pyrimidines and their use as angiogenesis inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338959-B2 | Diamino-pyrimidines and their use as angiogenesis inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-03-04 | — | — | US | disclosed |
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |
| EP-1487824-B1 | DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-06-20 | — | — | EP | disclosed |