Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 12/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 16/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.50 |
| ▸ | ATR | Q13535 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5224340 | 0.81 | HDAC1 (0.61) | HDAC2HDAC1HDAC3HDAC6HDAC11 | |
| SCHEMBL5227360 | 0.81 | HDAC1 (0.71) | HDAC2HDAC1HDAC3HDAC6HDAC11 | |
| SCHEMBL5226165 | 0.80 | ATR (0.45) | HDAC2HDAC1HDAC3ATRCYP3A4 | |
| SCHEMBL8281301 | 0.78 | CDK8 (0.57) | HDAC2HDAC1HDAC3HDAC6HDAC11 | |
| SCHEMBL1063809 | 0.76 | HDAC1 (0.65) | HDAC2HDAC1HDAC3HDAC6HDAC11 | |
| SCHEMBL1081615 | 0.76 | HDAC1 (0.54) | HDAC2HDAC1HDAC3HDAC6HDAC11 | |
| SCHEMBL1064710 | 0.75 | HDAC1 (0.64) | HDAC2HDAC1HDAC3HDAC6HDAC11 | |
| SCHEMBL1064912 | 0.74 | MDM4 (0.70) | HDAC2HDAC1HDAC3HDAC6HDAC11 | |
| SCHEMBL13888951 | 0.74 | HDAC1 (0.65) | HDAC2HDAC1HDAC3HDAC6HDAC11 | |
| SCHEMBL8235513 | 0.74 | HDAC1 (0.61) | HDAC2HDAC1HDAC3HDAC6HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501508-B1 | INHIBITORS OF HISTONE DEACETYLASE | ASTRAZENECA AB (SE) | 2007-02-21 | — | — | EP | disclosed |
| US-20050222410-A1 | Inhibitors of histone deacetylase | ASTRAZENECA AB (SE) | 2005-10-06 | — | — | US | disclosed |
| EP-1501508-A1 | INHIBITORS OF HISTONE DEACETYLASE | Astrazeneca AB (SE) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003092686-A1 | INHIBITORS OF HISTONE DEACETYLASE | ASTRAZENECA AB (SE) | 2003-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222410-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC3, HDAC11 | HDAC2 4/4885HDAC1 1/4885HDAC3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.