Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.48 |
| ▸ | KIT | P10721 | 15/20 | 0.48 |
| ▸ | FLT3 | P36888 | 14/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.44 |
| ▸ | AURKA | O14965 | 4/20 | 0.44 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.44 |
| ▸ | CSF1R | P07333 | 6/20 | 0.44 |
| ▸ | LYN | P07948 | 5/20 | 0.44 |
| ▸ | FLT1 | P17948 | 5/20 | 0.44 |
| ▸ | FLT4 | P35916 | 5/20 | 0.44 |
| ▸ | BLK | P51451 | 5/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.44 |
| ▸ | SRC | P12931 | 4/20 | 0.44 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.44 |
| ▸ | LCK | P06239 | 3/20 | 0.44 |
| ▸ | PLK4 | O00444 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.44 |
| ▸ | STK3 | Q13188 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3955233 | 0.89 | KDR (0.58) | KDRKITFLT3AURKBAURKA | |
| SCHEMBL3960272 | 0.83 | KDR (0.44) | KDRKITFLT3AURKBAURKA | |
| SCHEMBL3960509 | 0.83 | MAP4K4 (0.48) | KDRKITFLT3AURKBAURKA | |
| SCHEMBL3959575 | 0.82 | KDR (0.65) | KDRKITFLT3AURKBAURKA | |
| Hydrochloric Acid SCHEMBL3957832 | 0.81 | KDR (0.49) | KDRKITFLT3AURKBAURKA | |
| SCHEMBL3958638 | 0.80 | MKNK1 (0.44) | KDRKITFLT3AURKBCSF1R | |
| Trifluoroacetic Acid SCHEMBL3959583 | 0.79 | PRKD3 (0.48) | KDRKITFLT3AURKBCDK19 | |
| SCHEMBL3957614 | 0.79 | POLB (0.46) | KDRKIT | |
| SCHEMBL3956106 | 0.79 | KDR (0.46) | KDRKITFLT3AURKBAURKA | |
| SCHEMBL5471160 | 0.79 | ROCK1 (0.55) | KDRKITAURKBCDK19LIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765813-A1 | SUBSTITUTED INDAZOLES, COMPOSITIONS CONTAINING SAME, PREPARATION AND USE | Aventis Pharma S.A. (FR) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006003276-A1 | SUBSTITUTED INDAZOLES, COMPOSITIONS CONTAINING SAME, PREPARATION AND USE | AVENTIS PHARMA S.A. (FR) | 2006-01-12 | — | — | WO | disclosed |