Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 13/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5221073 | 0.93 | PTPN1 (0.46) | PTPN1SIRT3SMPD1 | |
| SCHEMBL3869519 | 0.90 | PTPN1 (0.59) | PTPN1SIRT3 | |
| SCHEMBL3863661 | 0.83 | PTPN1 (0.56) | PTPN1SIRT3 | |
| SCHEMBL4467637 | 0.81 | PTPN1 (0.60) | PTPN1 | |
| SCHEMBL5227305 | 0.81 | PTPN1 (0.49) | PTPN1SIRT3NR1H4 | |
| SCHEMBL4462504 | 0.80 | PTPN1 (0.58) | PTPN1 | |
| SCHEMBL4462374 | 0.79 | PTPN1 (0.57) | PTPN1 | |
| SCHEMBL13888098 | 0.79 | PTPN1 (0.55) | PTPN1SIRT3 | |
| SCHEMBL13888103 | 0.76 | PTPN1 (0.59) | PTPN1NR1H4 | |
| SCHEMBL4466918 | 0.76 | PTPN1 (0.59) | PTPN1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836182-A2 | HETEROCYCLYLBIPHENYL DERIVATES AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| EP-1814869-A2 | SUBSTITUTED AMINO ACIDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006055725-A2 | SUBSTITUTED AMINO ACIDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2006-05-26 | — | — | WO | disclosed |
| WO-2006055625-A2 | HETEROCYCLYLBIPHENYL DERIVATES AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2006-05-26 | — | — | WO | disclosed |