Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 6/20 | 0.33 |
| ▸ | FNTB | P49356 | 6/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226182 | 0.87 | FNTA (0.35) | HTTCYP11B1CYP11B2MAPTKDM4E | |
| SCHEMBL3568027 | 0.82 | HTT (0.51) | HTTCYP11B1CYP11B2KCNA5MAPT | |
| SCHEMBL3571215 | 0.74 | HTT (0.58) | HTTCYP11B1CYP11B2KCNA5MAPT | |
| SCHEMBL3571192 | 0.74 | HTT (0.57) | HTTCYP11B1CYP11B2KCNA5MAPT | |
| SCHEMBL3568025 | 0.69 | HTT (0.50) | HTTCYP11B1CYP11B2KCNA5MAPT | |
| SCHEMBL3578563 | 0.67 | FNTA (0.36) | HTTCYP11B1CYP11B2KCNA5MAPT | |
| SCHEMBL22076577 | 0.61 | HTT (0.62) | HTTCYP11B1CYP11B2KCNA5MAPT | |
| SCHEMBL29955489 | 0.61 | HTT (0.58) | HTTCYP11B1CYP11B2KCNA5MAPT | |
| SCHEMBL388288 | 0.60 | HTT (0.60) | HTTCYP11B1CYP11B2KCNA5MAPT | |
| SCHEMBL388289 | 0.60 | HTT (0.60) | HTTCYP11B1CYP11B2KCNA5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537114-B8 | ORGANIC COMPOUNDS AS AGENTS FOR THE TREATMENT OF ALDOSTERONE MEDIATED CONDITIONS | NOVARTIS AG (CH) | 2007-10-03 | — | — | EP | disclosed |
| EP-1537114-A1 | ORGANIC COMPOUNDS AS AGENTS FOR THE TREATMENT OF ALDOSTERONE MEDIATED CONDITIONS | Novartis AG (CH) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004014914-A1 | ORGANIC COMPOUNDS AS AGENTS FOR THE TREATMENT OF ALDOSTERONE MEDIATED CONDITIONS | NOVARTIS AG (CH) | 2004-02-19 | — | — | WO | disclosed |