Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.57 |
| ▸ | HTR3A | P46098 | 6/20 | 0.57 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.57 |
| ▸ | HTR3B | O95264 | 3/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.57 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.57 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229102 | 0.91 | CHRNA7 (0.57) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL14608939 | 0.82 | CHRNA7 (0.41) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5229487 | 0.82 | CHRNA7 (0.41) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL14608864 | 0.81 | CHRNA7 (0.49) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5227476 | 0.81 | CHRNA7 (0.49) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6100330 | 0.81 | SSTR3 (0.47) | — | |
| Hydrochloric Acid SCHEMBL7126791 | 0.80 | SSTR3 (0.46) | — | |
| SCHEMBL6480054 | 0.79 | CHRNA7 (0.57) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6489318 | 0.79 | CHRNA7 (0.55) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5917824 | 0.79 | CHRNA7 (0.60) | CHRNA7HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425286-B1 | SUBSTITUTED 7-AZA-[2.2.1]BICYCLOHEPTANES FOR THE TREATMENT OF DISEASES | PHARMACIA & UPJOHN CO LLC (US) | 2007-02-28 | — | — | EP | claimed |