Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 4/20 | 0.53 |
| ▸ | IGF1R | P08069 | 9/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229420 | 0.90 | SLC2A1 (0.55) | SLC2A1IGF1REGFRERBB2AURKA | |
| SCHEMBL3442344 | 0.84 | SLC2A1 (0.72) | SLC2A1IGF1REGFRERBB2AURKA | |
| SCHEMBL3441745 | 0.84 | SLC2A1 (0.64) | SLC2A1IGF1REGFRERBB2AURKA | |
| SCHEMBL3442000 | 0.83 | SLC2A1 (0.63) | SLC2A1IGF1REGFRERBB2AURKA | |
| SCHEMBL3442310 | 0.83 | SLC2A1 (0.52) | SLC2A1IGF1REGFRERBB2AURKA | |
| SCHEMBL3442091 | 0.82 | SLC2A1 (0.76) | SLC2A1IGF1REGFRERBB2AURKA | |
| SCHEMBL3537238 | 0.81 | MAPK8 (0.51) | SLC2A1IGF1REGFRERBB2AURKA | |
| SCHEMBL13118916 | 0.81 | IGF1R (0.56) | SLC2A1IGF1REGFRERBB2AURKA | |
| SCHEMBL3540982 | 0.81 | SLC2A1 (0.58) | SLC2A1IGF1REGFRERBB2AURKA | |
| SCHEMBL3442152 | 0.80 | IGF1R (0.57) | SLC2A1IGF1REGFRERBB2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828185-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2007-09-05 | — | — | EP | claimed |
| WO-2006068826-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-29 | — | — | WO | claimed |