Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.34 |
| ▸ | CHRNG | P07510 | 2/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.34 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | CHRND | Q07001 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14608827 | 1.00 | CHRNA7 (0.42) | CHRNA7CHRNB4CHRNA3HTR3EHTR3B | |
| SCHEMBL5227648 | 0.91 | CHRNA7 (0.52) | CHRNA7CHRNB4CHRNA3HTR3EHTR3B | |
| SCHEMBL14608860 | 0.91 | CHRNA7 (0.52) | CHRNA7CHRNB4CHRNA3HTR3EHTR3B | |
| SCHEMBL6480920 | 0.80 | CHRNA7 (0.40) | CHRNA7CHRNB4CHRNA3HTR3EHTR3B | |
| SCHEMBL5231121 | 0.80 | CHRNA7 (0.38) | CHRNA7CHRNB4CHRNA3HTR3EHTR3B | |
| SCHEMBL6489366 | 0.80 | CHRNA7 (0.42) | CHRNA7CHRNB4CHRNA3HTR3EHTR3B | |
| SCHEMBL5226254 | 0.80 | CHRNA7 (0.39) | CHRNA7CHRNB4CHRNA3HTR3EHTR3B | |
| SCHEMBL5229487 | 0.79 | CHRNA7 (0.41) | CHRNA7CHRNB4CHRNA3HTR3EHTR3B | |
| SCHEMBL14608939 | 0.79 | CHRNA7 (0.41) | CHRNA7CHRNB4CHRNA3HTR3EHTR3B | |
| SCHEMBL7124744 | 0.79 | DRD4 (0.39) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425286-B1 | SUBSTITUTED 7-AZA-[2.2.1]BICYCLOHEPTANES FOR THE TREATMENT OF DISEASES | PHARMACIA & UPJOHN CO LLC (US) | 2007-02-28 | — | — | EP | claimed |