Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ECE1 | P42892 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | KDM4B | O94953 | 1/20 | 0.35 |
| ▸ | KDM5C | P41229 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6139668 | 0.80 | MAPT (0.39) | KDM4EMAPTHSD17B10HDAC1HDAC2 | |
| SCHEMBL6139665 | 0.80 | MAPT (0.39) | KDM4EMAPTHSD17B10HDAC1HDAC2 | |
| SCHEMBL5229133 | 0.80 | MAPT (0.39) | KDM4EMAPTHSD17B10HDAC1HDAC2 | |
| SCHEMBL6139944 | 0.77 | KDM4E (0.41) | KDM4EMAPTHSD17B10HDAC1HDAC2 | |
| SCHEMBL6139945 | 0.77 | KDM4E (0.41) | KDM4EMAPTHSD17B10HDAC1HDAC2 | |
| SCHEMBL6139938 | 0.77 | KDM4E (0.41) | KDM4EMAPTHSD17B10HDAC1HDAC2 | |
| SCHEMBL13295205 | 0.75 | KDM4E (0.45) | KDM4EMAPTHSD17B10HDAC1HDAC2 | |
| SCHEMBL6139687 | 0.74 | KDM4E (0.37) | KDM4EMAPTHSD17B10HDAC1HDAC2 | |
| SCHEMBL5231257 | 0.74 | KDM4E (0.37) | KDM4EMAPTHSD17B10HDAC1HDAC2 | |
| SCHEMBL5231263 | 0.74 | KDM4E (0.37) | KDM4EMAPTHSD17B10HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150980-B1 | 16-HALOGEN-EPOTHILONE DERIVATIVES, METHOD FOR PRODUCING THEM AND THEIR PHARMACEUTICAL USE | BAYER SCHERING PHARMA AG (DE) | 2007-08-22 | — | — | EP | disclosed |