Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.76 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.73 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.73 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | VEGFA | P15692 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | PDE5A | O76074 | 1/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PDE1A | P54750 | 1/20 | 0.58 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542660 | 1.00 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3539891 | 1.00 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3545528 | 0.91 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL5791628 | 0.91 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3547980 | 0.91 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL7365947 | 0.90 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3546507 | 0.89 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3551242 | 0.89 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL5791539 | 0.89 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3553097 | 0.88 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432261-B2 | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| EP-1802615-A1 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044955-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |
| EP-1613590-A2 | 4-(3,4-DISUBSTITUTED PHENYL)-PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2006-01-11 | — | — | EP | disclosed |
| WO-2004094375-A2 | 4 - (3,4 - DISUBSTITUTED PHENYL) - PYRROLIDIN-2-ONE COMPOUNDS AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |