Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 9/20 | 0.45 |
| ▸ | CDK2 | P24941 | 9/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | GRK2 | P25098 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 2/20 | 0.33 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.33 |
| ▸ | TEC | P42680 | 2/20 | 0.33 |
| ▸ | BMX | P51813 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | LYN | P07948 | 1/20 | 0.32 |
| ▸ | HCK | P08631 | 1/20 | 0.32 |
| ▸ | FGR | P09769 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | FRK | P42685 | 1/20 | 0.32 |
| ▸ | BLK | P51451 | 1/20 | 0.32 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5228989 | 0.99 | CCNA2 (0.44) | CCNA2CDK2CCNA1NOS1GRK2 | |
| SCHEMBL5229094 | 0.91 | CCNA2 (0.46) | CCNA2CDK2CCNA1NOS1GRK2 | |
| SCHEMBL5227129 | 0.84 | CCNA2 (0.48) | CCNA2CDK2CCNA1 | |
| SCHEMBL5230170 | 0.84 | CDK2 (0.42) | CCNA2CDK2CCNA1PIK3CDPIK3CG | |
| SCHEMBL5224979 | 0.83 | CCNA2 (0.48) | CCNA2CDK2CCNA1NOS1GRK2 | |
| SCHEMBL5227572 | 0.79 | CDK2 (0.39) | CCNA2CDK2CCNA1NOS1GRK2 | |
| SCHEMBL5231075 | 0.77 | CCNA2 (0.51) | CCNA2CDK2CCNA1NOS1GRK2 | |
| SCHEMBL5264912 | 0.77 | CCNA2 (0.45) | CCNA2CDK2CCNA1NOS1WEE1 | |
| SCHEMBL5229177 | 0.77 | CCNA2 (0.50) | CCNA2CDK2CCNA1WEE1PKMYT1 | |
| Hydrochloric Acid SCHEMBL5229537 | 0.76 | CCNA2 (0.50) | CCNA2CDK2CCNA1NOS1GRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478357-B1 | TRICYCLIC PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PFIZER ITALIA SRL (IT) | 2007-01-31 | — | — | EP | claimed |