Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5230273 | 0.87 | MAPK14 (0.56) | MAPK14FGFR4KDRAURKAAURKB | |
| SCHEMBL3139200 | 0.80 | MEN1 (0.37) | FGFR4MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6618748 | 0.80 | MAPK14 (0.44) | MAPK14FGFR4KDRAURKAAURKB | |
| SCHEMBL6620382 | 0.79 | FGFR4 (0.61) | FGFR4KDRNPC1 | |
| SCHEMBL22165680 | 0.76 | FGFR4 (0.53) | FGFR4KDRAURKAAURKBNPC1 | |
| SCHEMBL3971040 | 0.76 | FGFR4 (0.64) | FGFR4KDRAURKAAURKBMAPT | |
| SCHEMBL22179316 | 0.76 | FGFR4 (0.40) | CRBNFGFR4MAPTMEN1KMT2A | |
| SCHEMBL5236612 | 0.74 | GFER (0.44) | DDB1CRBNMAPK14NPC1MAPT | |
| SCHEMBL5233582 | 0.73 | MAPK14 (0.79) | MAPK14FGFR4 | |
| SCHEMBL5233575 | 0.73 | MAPK14 (0.79) | MAPK14FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228070-B1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | HOFFMANN LA ROCHE (CH) | 2007-02-07 | — | — | EP | disclosed |
| US-6451804-B1 | Heteroalkylamino-substituted bicyclic nitrogen heterocycles | SYNTEX (U.S.A.) LLC | 2002-09-17 | — | — | US | disclosed |