SCHEMBL5229018

SCHEMBL5229018

CSc1ncc2c(n1)N(C)C(=O)N(c1c(Cl)cccc1Cl)C2

nearest known ligand 0.61

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
FGFR4 P22455 10/20 0.61
MAPK14 Q16539 2/20 0.51
LCK P06239 1/20 0.51
FGFR1 P11362 3/20 0.39
FGFR2 P21802 1/20 0.37
FGFR3 P22607 1/20 0.37
KDR P35968 1/20 0.37
KDM4E B2RXH2 1/20 0.37
LMNA P02545 1/20 0.37
MAPT P10636 1/20 0.37
SIK2 Q9H0K1 2/20 0.37
CSF1R P07333 1/20 0.37
SIK1 P57059 1/20 0.37
SIK3 Q9Y2K2 1/20 0.37
RPS6KA5 O75582 1/20 0.37
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6621872 0.87 FGFR4 (0.62) FGFR4MAPK14LCKFGFR1FGFR3
SCHEMBL6618207 0.86 FGFR4 (0.61) FGFR4MAPK14LCKFGFR1FGFR2
SCHEMBL6619641 0.85 FGFR4 (0.45) FGFR4MAPK14LCKKDM4ELMNA
SCHEMBL6619725 0.84 FGFR4 (0.47) FGFR4MAPK14LCKKDM4ELMNA
SCHEMBL6622839 0.84 FGFR4 (0.56) FGFR4MAPK14LCKFGFR1FGFR2
SCHEMBL6620598 0.82 FGFR4 (0.71) FGFR4FGFR1FGFR2FGFR3KDR
SCHEMBL5231241 0.81 FGFR4 (0.52) FGFR4MAPK14LCKFGFR1FGFR2
SCHEMBL20734018 0.80 FGFR4 (0.66) FGFR4FGFR1FGFR2FGFR3KDR
SCHEMBL23653235 0.80 FGFR4 (0.52) FGFR4MAPK14LCKFGFR1FGFR2
SCHEMBL6620382 0.79 FGFR4 (0.61) FGFR4LCKFGFR1FGFR3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3943087-A1 HETEROARYL COMPOUNDS AND USES THEREOF Celgene CAR LLC (BM) 2022-01-26 EP disclosed
EP-1228070-B1 HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE HOFFMANN LA ROCHE (CH) 2007-02-07 EP disclosed
EP-1228070-B1 HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE HOFFMANN LA ROCHE (CH) 2007-02-07 EP disclosed
EP-1123295-B1 BICYCLIC NITROGEN HETEROCYCLES HOFFMANN LA ROCHE (CH) 2004-09-29 EP disclosed
US-6451804-B1 Heteroalkylamino-substituted bicyclic nitrogen heterocycles SYNTEX (U.S.A.) LLC 2002-09-17 US disclosed
EP-1228070-A1 HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE F. HOFFMANN-LA ROCHE AG (CH) 2002-08-07 EP disclosed
EP-1123295-A1 BICYCLIC NITROGEN HETEROCYCLES F. HOFFMANN-LA ROCHE AG (CH) 2001-08-16 EP disclosed
WO-2001029042-A1 HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE F. HOFFMANN-LA ROCHE AG (CH) 2001-04-26 WO disclosed
US-6150373-A AMINO-SUBSTITUTED DIHYDROPYRIMIDO(4,5-D)PYRIMIDINONE DERIVATIVES; INHIBITORS OF THE T-CELL TYROSINE KINASE P56LCK; IMMUNOSUPPRESSANTS; ANTIINFLAMMATORY/-CARCINOGENIC AGENTS; BRONCHOPULMONARY, DERMATOLOGICAL AND CARDIOVASCULAR DISORDERS HOFFMANN-LA ROCHE INC. (US) 2000-11-21 US disclosed
WO-2000024744-A1 BICYCLIC NITROGEN HETEROCYCLES F. HOFFMANN-LA ROCHE AG (CH) 2000-05-04 WO disclosed