Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 13/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 12/20 | 0.54 |
| ▸ | CCNA1 | P78396 | 11/20 | 0.54 |
| ▸ | AURKA | O14965 | 8/20 | 0.54 |
| ▸ | PLK1 | P53350 | 4/20 | 0.54 |
| ▸ | EP300 | Q09472 | 5/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 4/20 | 0.45 |
| ▸ | CCND3 | P30281 | 4/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.45 |
| ▸ | TTK | P33981 | 3/20 | 0.45 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.45 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226915 | 0.91 | CDK2 (0.56) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL5228750 | 0.87 | CDK2 (0.59) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL5229361 | 0.85 | EP300 (0.45) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL5227516 | 0.75 | CDK2 (0.58) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL5225030 | 0.74 | CCNA2 (0.47) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL4154945 | 0.70 | CDK2 (1.00) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL5228949 | 0.70 | EP300 (0.41) | EP300CREBBPBRD4FLT3 | |
| SCHEMBL2187536 | 0.68 | CDK2 (0.56) | CDK2CCNA2CCNA1AURKAPLK1 | |
| SCHEMBL17794885 | 0.68 | CREBBP (1.00) | CDK2CCNA2CCNA1AURKAEP300 | |
| SCHEMBL5233166 | 0.67 | CCNA2 (0.78) | CDK2CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478357-B1 | TRICYCLIC PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PFIZER ITALIA SRL (IT) | 2007-01-31 | — | — | EP | claimed |