Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 13/20 | 0.49 |
| ▸ | CDK2 | P24941 | 13/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 13/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229284 | 0.87 | CCNA2 (0.58) | CCNA2CDK2CCNA1 | |
| SCHEMBL5230280 | 0.80 | CCNA2 (0.57) | CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL3206132 | 0.73 | GSR (0.53) | CDK2HCAR2KMT2ATSHR | |
| SCHEMBL28577870 | 0.72 | NPC1 (0.42) | HCAR2KMT2ATSHR | |
| SCHEMBL5233166 | 0.72 | CCNA2 (0.78) | CCNA2CDK2CCNA1 | |
| Hydrochloric Acid SCHEMBL6792455 | 0.72 | CCNA2 (0.74) | CCNA2CDK2CCNA1KMT2A | |
| SCHEMBL5231909 | 0.70 | HCAR2 (0.49) | HCAR2KMT2ATSHR | |
| SCHEMBL3517436 | 0.70 | HCAR2 (0.43) | HCAR2KMT2ATSHR | |
| SCHEMBL5227895 | 0.69 | CCNA2 (0.82) | CCNA2CDK2CCNA1 | |
| SCHEMBL6799888 | 0.68 | CCNA2 (0.80) | CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478357-B1 | TRICYCLIC PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PFIZER ITALIA SRL (IT) | 2007-01-31 | — | — | EP | claimed |
| CN-109384793-B | Thiol compound with HDAC6 inhibitory activity and application thereof | 沈阳药科大学 | 2021-05-07 | — | — | CN | disclosed |