Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 12/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.43 |
| ▸ | MB | P02144 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.39 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229744 | 1.00 | MAPK14 (0.55) | MAPK14MAPK8MAPK9MAPK10MB | |
| SCHEMBL3278620 | 0.84 | MAPK7 (0.47) | MAPK14MAPK8MAPK9MAPK10IKBKB | |
| SCHEMBL3278304 | 0.74 | MB (0.40) | MAPK14MBALDH1A1 | |
| SCHEMBL3279085 | 0.73 | MB (0.43) | MBAXLFLT3TYRO3MERTK | |
| SCHEMBL3278249 | 0.72 | MB (0.43) | MB | |
| SCHEMBL5229406 | 0.72 | MAPK14 (1.00) | MAPK14MAPK8MAPK9MAPK10AXL | |
| SCHEMBL5233582 | 0.72 | MAPK14 (0.79) | MAPK14MAPK8MAPK9MAPK10AXL | |
| SCHEMBL5232688 | 0.72 | MAPK14 (1.00) | MAPK14MAPK8MAPK9MAPK10AXL | |
| SCHEMBL5229413 | 0.72 | MAPK14 (1.00) | MAPK14MAPK8MAPK9MAPK10AXL | |
| SCHEMBL5233575 | 0.72 | MAPK14 (0.79) | MAPK14MAPK8MAPK9MAPK10AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228070-B1 | HETEROALKYLAMINO-SUBSTITUTED BICYCLIC NITROGEN HETEROCYCLES AS INHIBITORS OF P38 PROTEIN KINASE | HOFFMANN LA ROCHE (CH) | 2007-02-07 | — | — | EP | disclosed |