Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 11/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.74 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2074538 | 0.91 | CCR8 (0.82) | CCR8KCNH2CHRM2CYP2D6CYP3A4 | |
| SCHEMBL5194031 | 0.86 | CCR8 (0.72) | CCR8KCNH2CHRM2CYP2D6CYP3A4 | |
| SCHEMBL4234799 | 0.85 | CCR8 (1.00) | CCR8KCNH2CHRM2CYP2D6CYP3A4 | |
| SCHEMBL5227491 | 0.85 | CCR8 (0.82) | CCR8KCNH2CHRM2CYP2D6CYP3A4 | |
| SCHEMBL5197543 | 0.84 | CCR8 (0.71) | CCR8KCNH2CHRM2CYP2D6CYP3A4 | |
| SCHEMBL4187120 | 0.83 | CCR8 (1.00) | CCR8KCNH2CHRM2CYP2D6CYP3A4 | |
| SCHEMBL5225972 | 0.83 | CCR8 (0.75) | CCR8KCNH2CYP2D6CYP3A4ALDH1A1 | |
| SCHEMBL4180214 | 0.83 | CCR8 (0.83) | CCR8KCNH2CHRM2CYP2D6KDM4E | |
| SCHEMBL4236177 | 0.82 | CCR8 (0.73) | CCR8KCNH2CHRM2CYP2D6KDM4E | |
| SCHEMBL4233922 | 0.82 | CCR8 (0.78) | CCR8KCNH2CHRM2CYP2D6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869045-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | AstraZeneca AB (SE) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006107254-A1 | NOVEL DIAZASPIROALKANES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2006-10-12 | — | — | WO | disclosed |