Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340929 | 0.85 | HSD17B10 (0.42) | KDM4EUSP2ESR1POLBTHRB | |
| SCHEMBL3342434 | 0.84 | PSEN1 (0.50) | KDM4EUSP2ESR1POLBTHRB | |
| SCHEMBL3344471 | 0.84 | HSD17B10 (0.41) | KDM4EUSP2ESR1POLBTHRB | |
| SCHEMBL3340581 | 0.83 | PSEN1 (0.46) | KDM4EUSP2ESR1POLBTHRB | |
| SCHEMBL3343570 | 0.82 | KDM4E (0.39) | KDM4EUSP2ESR1POLBTHRB | |
| SCHEMBL3344119 | 0.81 | PSEN1 (0.46) | KDM4EUSP2ESR1POLBTHRB | |
| SCHEMBL3343225 | 0.79 | PSEN1 (0.46) | KDM4EUSP2ESR1POLBTHRB | |
| SCHEMBL3345093 | 0.79 | PSEN1 (0.47) | KDM4EUSP2ESR1POLBTHRB | |
| SCHEMBL3343883 | 0.78 | PSEN1 (0.45) | KDM4EUSP2ESR1POLBTHRB | |
| SCHEMBL3342650 | 0.78 | HSD17B10 (0.46) | KDM4EUSP2ESR1POLBTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1845089-A1 | Novel lactams and uses thereof | AstraZeneca AB (SE) | 2007-10-17 | — | — | EP | disclosed |