Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5226802 | 0.86 | KCNH2 (0.50) | KCNH2CYP3A4MGLL | |
| SCHEMBL509996 | 0.82 | KCNH2 (0.50) | KCNH2CYP3A4 | |
| SCHEMBL508346 | 0.81 | KCNH2 (0.54) | KCNH2CYP3A4 | |
| SCHEMBL509154 | 0.81 | KCNH2 (0.48) | KCNH2CYP3A4MGLL | |
| SCHEMBL1347408 | 0.80 | KCNH2 (0.48) | KCNH2CYP3A4 | |
| SCHEMBL14540417 | 0.79 | KCNH2 (0.47) | KCNH2CYP3A4MGLL | |
| SCHEMBL509896 | 0.79 | KCNH2 (0.50) | KCNH2CYP3A4 | |
| SCHEMBL10250900 | 0.74 | KCNH2 (0.78) | KCNH2CYP3A4 | |
| SCHEMBL509378 | 0.73 | KCNH2 (0.62) | KCNH2CYP3A4 | |
| SCHEMBL14302751 | 0.72 | KCNH2 (0.64) | KCNH2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377556-B1 | PYRAZOLE DERIVATIVES FOR TREATING HIV | PFIZER LTD (GB) | 2007-04-04 | — | — | EP | claimed |