Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | PDE5A | O76074 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5234200 | 0.88 | PDE5A (0.46) | PDE7APDE5AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL5229619 | 0.87 | PDE5A (0.48) | PDE7APDE5AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL5230203 | 0.86 | PDE7A (0.48) | PDE7APDE5AKDM4ECYP1A2HPGD | |
| SCHEMBL5230077 | 0.86 | PDE7A (0.49) | PDE7APDE5AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL5231816 | 0.85 | PDE5A (0.48) | PDE7APDE5AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL5228648 | 0.85 | PDE5A (0.53) | PDE7APDE5A | |
| SCHEMBL5231591 | 0.85 | PDE5A (0.47) | PDE7APDE5AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL5236194 | 0.84 | PDE7A (0.45) | PDE7APDE5AKDM4ECYP1A2CYP3A4 | |
| SCHEMBL5231510 | 0.84 | PDE7A (0.64) | PDE7APDE5A | |
| SCHEMBL5228186 | 0.84 | PDE7A (0.49) | PDE7APDE5AKDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1454897-B1 | PYRAZOLOPYRIMIDINONE DERIVATIVES HAVING PDE7-INHIBITORY ACTIVITY | ASUBIO PHARMA CO LTD (JP) | 2007-10-10 | — | — | EP | disclosed |
| EP-1454897-A1 | PYRAZOLOPYRIMIDINONE DERIVATIVES HAVING PDE7−INHIBITORY ACTIVITY | Daiichi Suntory Pharma Co., Ltd. (JP) | 2004-09-08 | — | — | EP | disclosed |