SCHEMBL5232017

SCHEMBL5232017

Cc1c(N2CCC(C3(N)CC(F)(F)C3)C2)c(F)c(N)c2c(=O)c(C(=O)O)cn([C@@H]3C[C@H]3F)c12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.50
KCNH2 Q12809 5/20 0.46
POLB P06746 2/20 0.46
CACNA1F O60840 1/20 0.46
MAPK1 P28482 1/20 0.46
CACNA1D Q01668 1/20 0.46
CACNA1S Q13698 1/20 0.46
CACNA1C Q13936 1/20 0.46
SCN5A Q14524 1/20 0.42
GSK3B P49841 8/20 0.41
TOP2A P11388 1/20 0.40
TOP2B Q02880 1/20 0.40
ALDH1A1 P00352 1/20 0.37
CHRM2 P08172 1/20 0.37
CHRM1 P11229 1/20 0.37
OPRM1 P35372 1/20 0.37
OPRD1 P41143 1/20 0.37
SLC2A1 P11166 1/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5232023 1.00 CYP3A4 (0.50) CYP3A4KCNH2POLBCACNA1FMAPK1
SCHEMBL6948764 0.93 CYP3A4 (0.58) CYP3A4KCNH2POLBCACNA1FMAPK1
SCHEMBL4673865 0.93 CYP3A4 (0.58) CYP3A4KCNH2POLBCACNA1FMAPK1
SCHEMBL5232419 0.91 CYP3A4 (0.51) CYP3A4KCNH2POLBCACNA1FMAPK1
SCHEMBL5231702 0.91 CYP3A4 (0.51) CYP3A4KCNH2POLBCACNA1FMAPK1
Hydrochloric Acid SCHEMBL4677081 0.86 CYP3A4 (0.59) CYP3A4KCNH2POLBCACNA1FMAPK1
SCHEMBL7076945 0.85 CYP3A4 (0.57) CYP3A4KCNH2POLBCACNA1FMAPK1
SCHEMBL4671147 0.85 CYP3A4 (0.57) CYP3A4KCNH2POLBCACNA1FMAPK1
SCHEMBL5235101 0.85 CYP3A4 (0.53) CYP3A4KCNH2POLBCACNA1FMAPK1
SCHEMBL5235109 0.85 CYP3A4 (0.53) CYP3A4KCNH2POLBCACNA1FMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0990654-B1 SUBSTITUTED CYCLOBUTYLAMINE DERIVATIVES DAIICHI SANKYO CO LTD (JP) 2007-11-14 EP claimed
US-6448266-B1 COMPOUNDS SUCH AS 2-AMINO-7-(3-(3-AMINO-1-FLUOROCYCLOBUTAN-3-YL)PYRROLIDIN-1-YL)-6-FLUORO-1-(2-FLUORO-1-CYCLOPROPYL)-8-METHYL-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID; ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS, PNEUMOCOCCUS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2002-09-10 US claimed
EP-0990654-A1 SUBSTITUTED CYCLOBUTYLAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2000-04-05 EP claimed
EP-0990654-B1 SUBSTITUTED CYCLOBUTYLAMINE DERIVATIVES DAIICHI SANKYO CO LTD (JP) 2007-11-14 EP disclosed
US-6448266-B1 COMPOUNDS SUCH AS 2-AMINO-7-(3-(3-AMINO-1-FLUOROCYCLOBUTAN-3-YL)PYRROLIDIN-1-YL)-6-FLUORO-1-(2-FLUORO-1-CYCLOPROPYL)-8-METHYL-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID; ANTIBACTERIAL ACTIVITY; STAPHYLOCOCCUS, PNEUMOCOCCUS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2002-09-10 US disclosed
EP-0990654-A1 SUBSTITUTED CYCLOBUTYLAMINE DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2000-04-05 EP disclosed