Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 9/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5229227 | 0.84 | HDAC4 (0.32) | KMT2A | |
| SCHEMBL3132676 | 0.77 | DPP4 (0.35) | DPP4DPP8DPP7DPP9NOTUM | |
| SCHEMBL3131535 | 0.64 | DPP4 (0.51) | DPP4DPP8DPP7NOTUM | |
| SCHEMBL19722716 | 0.58 | DPP4 (0.50) | DPP4DPP8DPP7NOTUM | |
| SCHEMBL30595341 | 0.58 | DPP4 (0.53) | DPP4DPP8DPP7DPP9NOTUM | |
| SCHEMBL14970399 | 0.56 | DPP4 (0.56) | DPP4DPP8DPP7DPP9KMT2A | |
| SCHEMBL29404199 | 0.54 | DPP4 (0.39) | DPP4DPP8DPP7NOTUM | |
| SCHEMBL3133282 | 0.54 | DPP4 (0.46) | DPP4DPP8DPP7NOTUM | |
| SCHEMBL15492434 | 0.54 | DPP4 (0.59) | DPP4DPP8DPP7DPP9 | |
| SCHEMBL9944486 | 0.54 | DPP4 (0.53) | DPP4DPP8DPP7NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554280-B1 | ANTIDIABETIC BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS | MERCK & CO INC (US) | 2007-08-15 | — | — | EP | disclosed |