Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 10/20 | 0.57 |
| ▸ | PDE6D | O43924 | 4/20 | 0.53 |
| ▸ | PDE6A | P16499 | 4/20 | 0.53 |
| ▸ | PDE6G | P18545 | 4/20 | 0.53 |
| ▸ | PDE6B | P35913 | 4/20 | 0.53 |
| ▸ | PDE6C | P51160 | 4/20 | 0.53 |
| ▸ | PDE6H | Q13956 | 4/20 | 0.53 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.53 |
| ▸ | ACHE | P22303 | 4/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14463492 | 0.88 | PDE5A (0.72) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL5230819 | 0.88 | PDE5A (0.72) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7710648 | 0.85 | PDE5A (0.79) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7448232 | 0.85 | PDE5A (0.79) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL7710652 | 0.85 | PDE5A (0.79) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL14463498 | 0.84 | PDE5A (0.53) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL14464011 | 0.82 | PDE5A (0.70) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL14464010 | 0.82 | PDE5A (0.70) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL14464006 | 0.82 | PDE5A (0.70) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL5231420 | 0.82 | PDE5A (0.70) | PDE5APDE6DPDE6APDE6GPDE6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448562-B1 | SUBSTITUTED TETRACYCLIC PYRROLOQUINOLONE DERIVATIVES USEFUL AS PHOSPHODIESTERASE INHIBITORS | ORTHO MCNEIL PHARMACEUTICAL CO (US) | 2007-07-25 | — | — | EP | disclosed |
| US-6686349-B2 | ADMINISTERING TO A PATIENT FOR THE TREATMENT OF SEXUAL DYSFUNCTION AN EFFECTIVE AMOUNT OF SUBSTITUTED TETRACYCLIC PYRROLOQUINOLONE DERIVATIVES | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-02-03 | — | — | US | disclosed |
| US-20030144268-A1 | Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2003-07-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144268-A1 | Substituted tetracyclic pyrroloquinolone derivatives useful as phosphodiesterase inhibitors | PDE5A, PDE3A, PDE3B | PDE5A 1/4885PDE6D 24/4885PDE6A 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.