Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.41 |
| ▸ | IDH1 | O75874 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.40 |
| ▸ | KRAS | P01116 | 2/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523370 | 1.00 | PLK1 (0.41) | PLK1IDH1BRD4BRDTKRAS | |
| SCHEMBL522747 | 0.93 | SOS1 (0.45) | PLK1IDH1BRD4BRDTKRAS | |
| SCHEMBL522746 | 0.93 | SOS1 (0.45) | PLK1IDH1BRD4BRDTKRAS | |
| SCHEMBL523421 | 0.92 | PLK1 (0.45) | PLK1IDH1BRD4BRDTTTK | |
| SCHEMBL523468 | 0.92 | PLK1 (0.45) | PLK1IDH1BRD4BRDTTTK | |
| SCHEMBL20815330 | 0.89 | IDH1 (0.44) | PLK1IDH1BRD4BRDTTTK | |
| SCHEMBL522332 | 0.89 | IDH1 (0.44) | PLK1IDH1BRD4BRDTTTK | |
| SCHEMBL524274 | 0.89 | IDH1 (0.44) | PLK1IDH1BRD4BRDTTTK | |
| SCHEMBL13551773 | 0.89 | PLK1 (0.41) | PLK1IDH1BRD4BRDTKRAS | |
| SCHEMBL13551774 | 0.87 | PLK1 (0.44) | PLK1IDH1BRD4BRDTTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120322793-A1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-12-20 | — | — | US | claimed |
| US-8278297-B2 | Protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-02 | — | — | US | claimed |
| US-20120028966-A1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-02 | — | — | US | claimed |
| EP-2356122-A1 | PROTEIN KINASE INHIBITORS | Vertex Pharmceuticals Incorporated (US) | 2011-08-17 | — | — | EP | claimed |
| WO-2010008454-A1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-01-21 | — | — | WO | claimed |
| EP-2356122-B1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2019-03-20 | — | — | EP | disclosed |
| US-8618106-B2 | Protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-12-31 | — | — | US | disclosed |
| US-20120322793-A1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-12-20 | — | — | US | disclosed |
| US-8278297-B2 | Protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-02 | — | — | US | disclosed |
| US-20120028966-A1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2356122-A1 | PROTEIN KINASE INHIBITORS | Vertex Pharmceuticals Incorporated (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010008454-A1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322793-A1 | PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | PLK1 86/4885IDH1 1107/4885BRD4 1038/4885 |
| US-20120028966-A1 | PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | PLK1 86/4885IDH1 1107/4885BRD4 1038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.