Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | FBP1 | P09467 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | GMNN | O75496 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871294 | 0.89 | EGFR (0.58) | EGFRKDM4EMAPTMAPK1FBP1 | |
| SCHEMBL5280120 | 0.89 | KDR (0.57) | EGFRMAPTMAPK1FBP1SRC | |
| SCHEMBL5237826 | 0.89 | EGFR (0.55) | EGFRALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL5238394 | 0.88 | EGFR (0.74) | EGFRKDM4EMAPTMAPK1FBP1 | |
| SCHEMBL5238896 | 0.82 | EGFR (0.65) | EGFRKDM4EMAPTMAPK1FBP1 | |
| Hydrochloric Acid SCHEMBL1467734 | 0.81 | KDR (0.60) | EGFRRAF1LCKABCG2KDR | |
| SCHEMBL27754788 | 0.81 | ABCG2 (0.72) | EGFRRAF1ABCG2 | |
| SCHEMBL1418243 | 0.80 | EGFR (0.78) | EGFRKDM4EMAPTMAPK1FBP1 | |
| Tyrphostin Ag-1478 SCHEMBL31079458 | 0.75 | EGFR (1.00) | EGFRKDM4EMAPTMAPK1FBP1 | |
| Tyrphostin Ag-1478 SCHEMBL29350062 | 0.75 | EGFR (1.00) | EGFRKDM4EMAPTMAPK1FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100378101-C | 1.3.4-triaza-phenalene and 1,3,4,6-tetraazaphenalene derivatives | HOFFMANN LA ROCHE (CH) | 2008-04-02 | — | — | CN | disclosed |
| EP-1680426-B1 | 1.3.4-TRIAZA-PHENALENE AND 1,3,4,6-TETRAAZAPHENALENE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2007-09-19 | — | — | EP | disclosed |
| US-7217717-B2 | Phenalene derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-05-15 | — | — | US | disclosed |
| US-7217717-B2 | Phenalene derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-05-15 | — | — | US | disclosed |
| CN-1805964-A | 1,3, 4-triaza-phenalene and 1,3,4, 6-tetraazaphenalene derivatives | HOFFMANN LA ROCHE (CH) | 2006-07-19 | — | — | CN | disclosed |
| US-20040254205-A1 | Phenalene derivatives | LUK KIN-CHUN (US) | 2004-12-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040254205-A1 | Phenalene derivatives | EGFR, ERBB2, ERBB4 | EGFR 1/4885KDM4E 2015/4885MAPT 3120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.