Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | AXL | P30530 | 3/20 | 0.46 |
| ▸ | MERTK | Q12866 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | MELK | Q14680 | 3/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5169216 | 0.95 | HDAC1 (0.52) | HDAC1AXLMERTKJAK2MELK | |
| SCHEMBL5166916 | 0.94 | HDAC1 (0.48) | HDAC1AXLMERTKJAK2MELK | |
| SCHEMBL5165601 | 0.81 | HDAC1 (0.56) | HDAC1AXLMERTKJAK2MELK | |
| SCHEMBL5168509 | 0.81 | HDAC1 (0.46) | HDAC1AXLMERTKJAK2MELK | |
| SCHEMBL5169162 | 0.81 | HDAC1 (0.48) | HDAC1AXLMERTKJAK2MELK | |
| SCHEMBL5164995 | 0.79 | HDAC1 (0.53) | HDAC1AXLMERTKJAK2LTA4H | |
| SCHEMBL5169450 | 0.79 | MELK (0.44) | HDAC1AXLMERTKJAK2MELK | |
| SCHEMBL5188483 | 0.78 | LSS (0.52) | HDAC1JAK2LTA4HHRH3HRH2 | |
| SCHEMBL5191116 | 0.78 | LSS (0.52) | HDAC1JAK2LTA4HHRH3HRH2 | |
| SCHEMBL5165935 | 0.78 | HDAC1 (0.63) | HDAC1JAK2LTA4HHRH3CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771438-A1 | 1-3 SUBSTITUTED CYCLOAMINO DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTOR ANTAGONISTS | Pfizer Products Incorporated (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006011042-A1 | 1, 3 SUBSTITUTED CYCLOAMINO DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2006-02-02 | — | — | WO | disclosed |