Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2089202 | 0.93 | MAPT (0.62) | MAPTRAB9AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2089200 | 0.93 | MAPT (0.62) | MAPTRAB9AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2086889 | 0.93 | MAPT (0.62) | MAPTRAB9AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2086891 | 0.93 | MAPT (0.62) | MAPTRAB9AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5248996 | 0.93 | MAPT (0.62) | MAPTRAB9AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5241777 | 0.86 | POLB (0.63) | MAPTRAB9AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL5241770 | 0.86 | POLB (0.63) | MAPTRAB9AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL13144984 | 0.84 | MAPT (0.56) | MAPTRAB9AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2385628 | 0.84 | MAPT (0.56) | MAPTRAB9AALDH1A1GAASMN1; SMN2 | |
| SCHEMBL2386013 | 0.84 | MAPT (0.56) | MAPTRAB9AALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748999-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005075461-A1 | IMIDAZOLO-5-YL-2-ANILINOPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | disclosed |