Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2977372 | 0.86 | SMPD1 (0.43) | SMPD1EPAS1TSHRACKR3SIGMAR1 | |
| SCHEMBL13202874 | 0.77 | EPAS1 (0.50) | SMPD1EPAS1TSHRACKR3SIGMAR1 | |
| SCHEMBL2977889 | 0.76 | SMPD1 (0.50) | SMPD1EPAS1TSHRACKR3SIGMAR1 | |
| SCHEMBL5282322 | 0.75 | EPAS1 (0.42) | EPAS1KMT2AACP1KDM4ENPC1 | |
| SCHEMBL2966689 | 0.73 | MEN1 (0.45) | EPAS1MEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL2969567 | 0.71 | KMT2A (0.43) | EPAS1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL6109034 | 0.69 | EPAS1 (0.40) | EPAS1TSHRMEN1KMT2APTPN1 | |
| SCHEMBL2977932 | 0.67 | EPAS1 (0.45) | EPAS1TSHRACKR3SIGMAR1TP53 | |
| SCHEMBL2977514 | 0.65 | CASR (0.41) | EPAS1MEN1KMT2AACP1KDM4E | |
| SCHEMBL2975434 | 0.65 | EPAS1 (0.46) | EPAS1TSHRACKR3SIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853573-A1 | BENZISOTHIAZOLES USEFUL FOR TREATING OR PREVENTING HCV INFECTION | Rigel Pharmaceuticals, Inc. (US) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006091858-A1 | BENZISOTHIAZOLES USEFUL FOR TREATING OR PREVENTING HCV INFECTION | RIGEL PHARMACEUTICALS, INC. (US) | 2006-08-31 | — | — | WO | disclosed |