Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3606259 | 0.91 | NR3C2 (0.48) | NR3C2PDE4DMAPTLMNAHPGD | |
| SCHEMBL3611670 | 0.90 | NR3C2 (0.47) | NR3C2PDE4DMAPTLMNAALDH1A1 | |
| SCHEMBL3614491 | 0.83 | MAPK9 (0.43) | NR3C2PDE4DMAPTLMNAALDH1A1 | |
| SCHEMBL3612122 | 0.81 | NR3C2 (0.47) | NR3C2MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL3609867 | 0.79 | NR3C2 (0.57) | NR3C2PDE4DMAPTLMNAALDH1A1 | |
| SCHEMBL3609486 | 0.76 | NR3C2 (0.51) | NR3C2MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL3594420 | 0.73 | NR3C2 (0.51) | NR3C2MAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL13343000 | 0.72 | PDE4A (0.47) | PDE4DPDE4B | |
| SCHEMBL3608828 | 0.72 | PDE4A (0.47) | PDE4DPDE4B | |
| SCHEMBL15556699 | 0.71 | NR3C2 (0.54) | NR3C2MAPTKDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799673-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006044528-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |