Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5279706 | 0.80 | PARP1 (0.40) | PKN2MKNK2PARP1 | |
| SCHEMBL1399865 | 0.73 | KDM4E (0.45) | KDM4EALDH1A1HPGDMCHR1THRA | |
| SCHEMBL1399838 | 0.73 | MAPK14 (0.53) | KCNH2 | |
| SCHEMBL1399845 | 0.70 | MAPK14 (0.44) | KDM4EALDH1A1HPGDTHRAMEN1 | |
| SCHEMBL30343857 | 0.69 | KDM4E (0.52) | KDM4EALDH1A1HPGDCHEK1RPS6KB1 | |
| SCHEMBL1399786 | 0.69 | MAPK14 (0.52) | — | |
| SCHEMBL5274702 | 0.68 | CHUK (0.44) | KDM4EALDH1A1RPS6KB1MCHR1MEN1 | |
| SCHEMBL1399881 | 0.67 | MAPK14 (0.48) | KDM4EALDH1A1HPGDDYRK3MEN1 | |
| SCHEMBL1400011 | 0.66 | MAPK14 (0.51) | — | |
| SCHEMBL1399863 | 0.66 | MAPK14 (0.52) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831174-A1 | AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067444-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |